Houston Astros vs. San Francisco Giants Odds, Picks and Predictions

THE Houston Astros (30-36) and San Francisco Giants (32-34) begin a 3-game interleague series at Oracle Park on Monday. The first pitch is scheduled for 9:45 p.m. ET (MLB Network). Let’s analyze the FanDuel Sportsbook lines around the Astros vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; The Giants won 2-1 in 2023

The Astros took 2 of 3 from the Los Angeles Angels this weekend, winning a series for the second straight time since June 3. Houston also won the previous interleague series against the St. Louis Cardinals from Monday to Wednesday.

On the road, Houston has struggled, going just 8-13 over the last 21 games, not including two neutral-site games in Mexico City on April 27-28.

The Under are 3-1 in Houston’s last 4 games while being 12-3 in their last 15 outings. On the road, the total fell to 8-1 over the last 9 tries.

For the Giants, they suffered a 7-2 loss in the Interleague Series finale against the Texas Rangers on Sunday, but San Francisco won the first 2 battles in this series. However, the Giants are only 3-7 in the last 10 games, and they have also lost the last 4 games at home.

Astros among Giants’ projected starters

RHP Spencer Arrighetti against LHP Kyle Harrison

Arrighetti (3-5, 5.79 ERA) is making his 11th start. He has a 1.67 WHIP, 5.0 BB/9 and 10.6 K/9 in 46 2/3 IP.

• Last start: No decision, 3 IP, 1 ER, 3 H, 3 BB, 4 K in an 8-5 home win over the St. Louis Cardinals last Tuesday
• 2024 road splits: 1-4, 7.54 ERA (22 2/3 IP, 19 ER), 1.90 WHIP, .309 opponents’ batting average (OBA), 4 HR, 14 BB, 29 K in 5 starts

Harrison (4-3, 4.18 ERA) is making his 14th start. He has a 1.39 WHIP, 3.0 BB/9 and 6.0 K/9 in 71 IP.

• Last start: Loss, 6 IP, 4 R (3 ER), 8 H, 0 BB, 5 K in an 8-5 road loss to the Arizona Diamondbacks last Tuesday
• 2024 Home Splits: 1-1, 4.65 ERA (31 IP, 16 ER), 1.45 WHIP, .286 OBA, 3 HR, 9 BB, 34 K in 6 starts

Win your fantasy baseball league with BaseballHQ.com. For decades, BHQ has been helping players like you win! BHQ offers Draft Prep and full season memberships. Sign up today and start earning!

Astros alongside Giants

Powered by FanDuel Sportsbook; Go to the USA TODAY Sports Sports Betting Scores & Odds hub for a complete list. Lines last updated at 6:26 a.m. ET.

• Money Line (ML): Astros -118 (bet $118 to win $100) | Giants +100 (bet $100 to win $100)
• Running Line (RL)/Against the Spread (ATS): Astros -1.5 (+146) | Giants +1.5 (-176)
• More/Less (Y/U): 8 (O: -122 | U: +100)

Astros picks and predictions at Giants

Prediction

Giants 7, Astros 5

Money line

THE GIANTS (+100) are a decent game to tie in this interleague series opener at home.

Arrighetti has been horrible for the Astros (-118), especially on the road, and it won’t help that there’s a jetstream blowing toward the left-center field power alley.

The Astros just can’t seem to build momentum or play with consistency.

Running Line/Against the Spread

If you’re a little more conservative and just can’t play straight in San Francisco, support GIANTS +1.5 (-176) the price is not exorbitant for a little insurance.

The Giants have lost 4 straight at home, so they are anything but a slam-dunk game. Sure, the Astros -1.5 (+146) are 6 games under .500 this season, and Arrighetti has an ERA north of 7 on the road.

More less

MORE THAN 8 (-122) is the best play on the board in this opening game of the interleague series.

The wind will blow from home plate toward the left-center force field lane at a speed of 8 to 11 mph.

While the Under has dominated the Astros as of late, the Over is 5-2 in Arrighetti’s last 7 starts.

For the Giants, the Over is 6-3 in the last 9 outings and 9-4 in the previous 13 home games. The total has also increased in 4 of southpaw Harrison’s last 5 starts.

Play our free daily Choose Them Challenge and win! Play now!

For more choices and advice on sports bettingcheck out SportsbookWire.com and BetFTW.

Follow Kevin J. Erickson on Twitter/X. Follow SportsbookWire on Twitter/X And Like us on Facebook.

Additional MLB coverage:
BaseballHQ Fantasy Baseball